Bequest and Wealth Accumulation: Are Some Pieces of the Puzzle Missing?

Leptin and transplantation: pieces are still missing in the puzzle.

Missing Pieces in the NF-κB Puzzle

stimulate the migration and maturation of lymphocytes. Furthermore, NF-␬B is central for the overall immune response through its ability to activate genes coding for and cyclin D1, that are critical for apoptotic processes (Karin and Lin, 2002). regulation is the I␬B kinase (IKK) complex. This review is focused on recent progress as well as unanswered intriguing and outstanding questions that a...

1918 Influenza, a Puzzle with Missing Pieces

hanks and Brundage offer thought-provoking hypotheses about infl uenza pathogenesis during the catastrophic 1918–1919 pandemic (1). Although we neither agree nor disagree with their views, its central hypothesis of T-cell–mediated immunopathogenesis begs examination of past events in light of modern immunologic and virologic understanding. We also emphasize that effects of the pandemic virus sh...

Adjuvant therapy for breast cancer: we are solving the puzzle, but pieces are still missing.

EDITORIALS Two interesting trials from the Adjuvant Breast Cancer (ABC) Trials Collaborative Group (1,2) are reported in this issue of the Journal. Although their interpretation is impeded by the lack of estrogen receptor (ER) measurements in more than 40% of patients , these trials provide important information regarding adju-vant therapy for women with breast cancer. The ABC Ovarian Ablation ...

Searching for missing pieces of the sex-determination puzzle.

Little is known of the mechanisms whereby the mammalian indifferent gonad develops into a testis or ovary. In XY individuals, Sry, the mammalian testis-determining gene, is expressed in the pre-Sertoli cells, which then differentiate into Sertoli cells. Other cell types, which include the germ cells, the steroidogenic cells and the connective tissue cells, must then be instructed to develop in ...